New Concept of Competitive Inhibition of the Renal Tubular Excretion of Penicillin
It has been found that the excretion of penicillin by a renal tubular transport mechanism could be physiologically inhibited reversibly. The basis for this effect is thought to be one of substrate competition between penicillin, which is excreted by the tubules, and 4 prime -carboxyphenyl-methanesul...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1947-01, Vol.105 (2717), p.94-95 |
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| container_end_page | 95 |
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| container_issue | 2717 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 105 |
| creator | Beyer, Karl H. |
| description | It has been found that the excretion of penicillin by a renal tubular transport mechanism could be physiologically inhibited reversibly. The basis for this effect is thought to be one of substrate competition between penicillin, which is excreted by the tubules, and 4 prime -carboxyphenyl-methanesulfonanilide, which is essentially refractory to excretion by that transport mechanism. |
| doi_str_mv | 10.1126/science.105.2717.94 |
| format | Article |
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The basis for this effect is thought to be one of substrate competition between penicillin, which is excreted by the tubules, and 4 prime -carboxyphenyl-methanesulfonanilide, which is essentially refractory to excretion by that transport mechanism.</description><subject>Biochemical Phenomena</subject><subject>Biological Transport</subject><subject>Blood</subject><subject>Blood plasma</subject><subject>Dosage</subject><subject>Enzymes</subject><subject>Excretion</subject><subject>Humans</subject><subject>Kidney - physiology</subject><subject>Old Medline</subject><subject>Penicillin</subject><subject>Penicillins</subject><subject>Renal plasma flow</subject><subject>Renal tubules</subject><subject>Technical Papers</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1947</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLw0AUhQdRbK3-AkWyc5V455XJLKVULRSVUtchM7mhU_Iyk_j496a04uqey3fOWRxCrilElLL43luHtcWIgoyYoirS4oRMKWgZagb8lEwBeBwmoOSEXHi_AxiZ5udkQlUCWslkStYv-BXMm7Gn7YOmGGXVYu9694nBst46M8qm3pN-i8Ea66wMNoMZyqwLFt-2wz_8hrWzrixdfUnOiqz0eHW8M_L-uNjMn8PV69Ny_rAKLZeiD7mRNqdSoTFGATKwVOjEai2UyTOhGcaGGTAx5QqSwsbAJMshZ4Aiy0DxGbk79LZd8zGg79PKeYtlmdXYDD5VnFNBNcjRyQ9O2zXed1ikbeeqrPtJKaT7LdPjluMv0_2WqRZj6vbYP5gK8__McbzRcHMw7HzfdP88VlKKhP8CHZJ60A</recordid><startdate>19470124</startdate><enddate>19470124</enddate><creator>Beyer, Karl H.</creator><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19470124</creationdate><title>New Concept of Competitive Inhibition of the Renal Tubular Excretion of Penicillin</title><author>Beyer, Karl H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-3b5cd157ebbb70e20c1498c9947bda492e6b2b0b613708fc60252d0d20e4aa073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1947</creationdate><topic>Biochemical Phenomena</topic><topic>Biological Transport</topic><topic>Blood</topic><topic>Blood plasma</topic><topic>Dosage</topic><topic>Enzymes</topic><topic>Excretion</topic><topic>Humans</topic><topic>Kidney - physiology</topic><topic>Old Medline</topic><topic>Penicillin</topic><topic>Penicillins</topic><topic>Renal plasma flow</topic><topic>Renal tubules</topic><topic>Technical Papers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beyer, Karl H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beyer, Karl H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Concept of Competitive Inhibition of the Renal Tubular Excretion of Penicillin</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1947-01-24</date><risdate>1947</risdate><volume>105</volume><issue>2717</issue><spage>94</spage><epage>95</epage><pages>94-95</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>It has been found that the excretion of penicillin by a renal tubular transport mechanism could be physiologically inhibited reversibly. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1947-01, Vol.105 (2717), p.94-95 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733141905 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Biochemical Phenomena Biological Transport Blood Blood plasma Dosage Enzymes Excretion Humans Kidney - physiology Old Medline Penicillin Penicillins Renal plasma flow Renal tubules Technical Papers |
| title | New Concept of Competitive Inhibition of the Renal Tubular Excretion of Penicillin |
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