New Concept of Competitive Inhibition of the Renal Tubular Excretion of Penicillin

New Concept of Competitive Inhibition of the Renal Tubular Excretion of Penicillin

It has been found that the excretion of penicillin by a renal tubular transport mechanism could be physiologically inhibited reversibly. The basis for this effect is thought to be one of substrate competition between penicillin, which is excreted by the tubules, and 4 prime -carboxyphenyl-methanesul...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1947-01, Vol.105 (2717), p.94-95
1. Verfasser: Beyer, Karl H.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemical Phenomena
Biological Transport
Blood
Blood plasma
Dosage
Enzymes
Excretion
Humans
Kidney - physiology
Old Medline
Penicillin
Penicillins
Renal plasma flow
Renal tubules
Technical Papers
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Zusammenfassung:It has been found that the excretion of penicillin by a renal tubular transport mechanism could be physiologically inhibited reversibly. The basis for this effect is thought to be one of substrate competition between penicillin, which is excreted by the tubules, and 4 prime -carboxyphenyl-methanesulfonanilide, which is essentially refractory to excretion by that transport mechanism.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.105.2717.94