Highly Functional Group Tolerance in Copper-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles under Mild Conditions

A copper-catalyzed process has been developed for the N-arylation reaction under very mild conditions in the absence of additional ligand. This protocol could not only tolerate an array of thermally sensitive functional groups, but also achieve high chemoselectivity.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2009-03, Vol.74 (5), p.2200-2202
Hauptverfasser:	Zhu, Liangbo, Li, Gaocan, Luo, Liang, Guo, Peng, Lan, Jingbo, You, Jingsong
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Chemistry Copper - chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Heterocyclic compounds with only one n hetero atom and condensed derivatives Hydrocarbons, Halogenated - chemistry Molecular Structure Nitrogen - chemistry Organic chemistry Preparations and properties Stereoisomerism Temperature
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Beschreibung
Zusammenfassung:	A copper-catalyzed process has been developed for the N-arylation reaction under very mild conditions in the absence of additional ligand. This protocol could not only tolerate an array of thermally sensitive functional groups, but also achieve high chemoselectivity.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo802669b