Adjunctive MSCs enhance myelin formation by xenogenic oligodendrocyte precursors transplanted in the retina

Dear Editor, We examined myelin formation by oligodendrocytes co-transplanted with immunosuppressive mesenchymal stem cells （MSCs）. Oligodendrocyte precursor cells （OPCs） were grafted into the mouse retina, and graft survival and maturation was determined with or without adjunctive MSCs. Green fluor...

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Veröffentlicht in:	Cell research 2010-06, Vol.20 (6), p.728-731
Hauptverfasser:	Arriola, Aileen, Kiel, Mary E, Shi, Yufang, McKinnon, Randall D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2606 631/532/2074 692/698/1688/512/2613/1786 Animals Biomedical and Life Sciences Cell Biology Cell Differentiation - physiology Cells, Cultured Coculture Techniques Graft Survival - physiology letter-to-the-editor Life Sciences Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice MSCs Myelin Sheath - metabolism Oligodendroglia - cytology Oligodendroglia - metabolism Oligodendroglia - transplantation Retina - cytology Retina - metabolism Stem Cells - cytology Stem Cells - metabolism Transplantation, Heterologous - methods Up-Regulation - physiology 前体细胞少突胶质细胞异种移植绿色荧光蛋白视网膜骨髓基质细胞
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Zusammenfassung:	Dear Editor, We examined myelin formation by oligodendrocytes co-transplanted with immunosuppressive mesenchymal stem cells （MSCs）. Oligodendrocyte precursor cells （OPCs） were grafted into the mouse retina, and graft survival and maturation was determined with or without adjunctive MSCs. Green fluorescent protein （GFP）-labeled MSCs were present at 2 but not 6 weeks post transplant,
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2010.63