AML with CBFB–MYH11 rearrangement demonstrate RAS pathway alterations in 92% of all cases including a high frequency of NF1 deletions

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Veröffentlicht in:	Leukemia 2010-05, Vol.24 (5), p.1065-1069
Hauptverfasser:	Haferlach, C, Dicker, F, Kohlmann, A, Schindela, S, Weiss, T, Kern, W, Schnittger, S, Haferlach, T
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/737 631/80/86 692/699/67/1990/283/1897 Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Research Chromosome Banding Critical Care Medicine Gene Deletion Gene Expression Profiling Gene mutations Gene Rearrangement Genes, ras - genetics Genotype Health aspects Hematologic and hematopoietic diseases Hematology Humans Intensive Internal Medicine letter-to-the-editor Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Medicine Medicine & Public Health Neurofibromin 1 - genetics Oligonucleotide Array Sequence Analysis Oncogene Proteins, Fusion - genetics Oncology Physiological aspects Polymorphism, Single Nucleotide Ras genes Transcription factors
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