Microbial hydroxylation of progesterone with Acremonium strictum

Microbial hydroxylation of progesterone with Acremonium strictum

Microbial hydroxylation of progesterone occurred in the culture of Acremonium strictum PTCC 5282 to produce two hydroxylated pregnene-like steroids. The metabolites were purified and characterized using spectroscopic methods and identified as 15α-hydroxyprogesterone and 15α-hydroxydeoxycorticosteron...

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Veröffentlicht in:FEMS microbiology letters 2003-05, Vol.222 (2), p.183-186
Hauptverfasser: Faramarzi, Mohammad Ali, Tabatabaei Yazdi, Mojtaba, Amini, Mohsen, Zarrini, Gholamreza, Shafiee, Abbas
Format: Artikel
Sprache:eng
Schlagworte:
Acremonium - metabolism
Acremonium strictum
Biological and medical sciences
Biotransformation
Fundamental and applied biological sciences. Psychology
Hydroxycorticosteroids - chemistry
Hydroxycorticosteroids - metabolism
Hydroxylation
Hydroxyprogesterones - chemistry
Hydroxyprogesterones - metabolism
Magnetic Resonance Spectroscopy
Microbial hydroxylation
Microbiology
Miscellaneous
Mycology
Progesterone
Progesterone - chemistry
Progesterone - metabolism
Steroid
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Zusammenfassung:Microbial hydroxylation of progesterone occurred in the culture of Acremonium strictum PTCC 5282 to produce two hydroxylated pregnene-like steroids. The metabolites were purified and characterized using spectroscopic methods and identified as 15α-hydroxyprogesterone and 15α-hydroxydeoxycorticosterone.
ISSN:0378-1097
1574-6968
DOI:10.1016/S0378-1097(03)00257-X