Acute cardiovascular response in anabolic androgenic steroid users performing maximal treadmill exercise testing

Maior, AS, Simão, R, Salles, BF, Alexander, JL, Rhea, M, and Nascimento, JHM. Acute cardiovascular response in anabolic androgenic steroid users performing maximal treadmill exercise testing. J Strength Cond Res 24(6)1688-1695, 2010-The purpose of this study was to investigate the cardiovascular effects of anabolic androgenic steroid (AAS) use, specifically the hemodynamic response, during maximal treadmill exercise testing by comparing the exercise response between users of AAS (U-AAS) and non-AAS users (N-AAS). Twenty-four men (n = 12; 29 ± 3.4 years and n = 12; 29.5 ± 8.2 years for the U-AAS and N-AAS groups, respectively) with regular participation in both resistance (mean = 6 d·wk) and aerobic exercise (mean = 2 d·wk) volunteered for the study. Both groups of subjects completed a ramp-protocol maximal treadmill exercise test to volitional fatigue. Several hemodynamic and metabolic measures were obtained before, during, and after testing. The results demonstrate for the first time that chronic administration of high doses of AAS (355.4 ± 59.47 mg·wk) lead to hemodynamic and metabolic response impairment. In conclusion, the chronotropic significant incompetence in the current study was reflected by an exaggerated hemodynamic response to exercise. Furthermore, the findings suggest that nonusers of AAS showed increases in o2max when compared to the AAS group. Therefore, this study provides a contraindication to AAS use, especially in those at increased risk of cardiovascular events.