Electrical Detection of DNA Hybridization with Single-Base Specificity Using Transistors Based on CVD-Grown Graphene Sheets

Large‐sized chemical vapor deposited graphene films configured as solution‐gated transistors can label‐freely and electrically detect DNA hybridization with single‐base specificity. The gate voltage which gives the minimum device conductance (Vg,min) is sensitive to the charge transfer between DNA molecules and graphene, and thus is used to detect the DNA hybridization. The DNA detection is attributed to the electronic n‐doping from DNA to graphene rather than the electrostatic gating effect or impurity screening effect.