Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum

Quality controls were performed as described previously.6 The Cochran-Armitage trend test was used to test for association between each SNP and disease status by using PLINK.7 AÂ linear regression analysis was performed to test for associations between individual genetic markers and log-adjusted tot...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2010-06, Vol.125 (6), p.1403-1407.e4
Hauptverfasser:	Gao, Pei-Song, MD, PhD, Rafaels, Nicholas M., MS, Mu, Deguang, MD, PhD, Hand, Tracey, MS, Murray, Tanda, MHS, Boguniewicz, Mark, MD, Hata, Tissa, MD, Schneider, Lynda, MD, Hanifin, Jon M., MD, Gallo, Richard L., MD, Gao, Li, MD, PhD, Beaty, Terri H., PhD, Beck, Lisa A., MD, Leung, Donald Y.M., MD, Barnes, Kathleen C., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Allergic diseases Allergy and Immunology Biological and medical sciences Continental Population Groups Cross cultural studies Cytokines - genetics Cytokines - immunology Cytokines - metabolism Dermatitis, Atopic - genetics Dermatitis, Atopic - immunology Dermatitis, Atopic - physiopathology Disease DNA Mutational Analysis Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Frequency Genetic Association Studies Genetic Variation Human viral diseases Humans Immunopathology Infectious diseases Kaposi Varicelliform Eruption - genetics Kaposi Varicelliform Eruption - immunology Kaposi Varicelliform Eruption - physiopathology Medical sciences Polymorphism, Single Nucleotide Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Receptors, Interleukin-7 - genetics Receptors, Interleukin-7 - metabolism Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin allergic diseases. Stinging insect allergies Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
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Beschreibung
Zusammenfassung:	Quality controls were performed as described previously.6 The Cochran-Armitage trend test was used to test for association between each SNP and disease status by using PLINK.7 AÂ linear regression analysis was performed to test for associations between individual genetic markers and log-adjusted total serum IgE (tIgE) concentrations and log-adjusted Eczema Area and Severity Index (EASI) scores, and a multiple logistic regression model was used to test for SNP-SNP interactions among cases only between TSLP and its receptors by using SAS version 9.1 software (SAS Institute, Inc, Cary, NC).
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2010.03.016