Role of Ischemic Preconditioning in Liver Surgery and Hepatic Transplantation

Introduction The purpose of this review is to summarize intraoperative surgical strategies available to decrease ischemia–reperfusion injury associated with liver resection and liver transplantation. Material and method We conducted a critical review of the literature evaluating the potential applications of hepatic ischemic preconditioning (IPC) for hepatic resection surgery and liver transplantation. In addition, we provide a basic bench-to-bedside summary of the liver physiology and cell signaling mechanisms that account for the protective effects seen with hepatic IPC.