Expeditious Synthesis of Highly Substituted Indolizinones via a Palladium-Catalyzed Domino Sequence

Expeditious Synthesis of Highly Substituted Indolizinones via a Palladium-Catalyzed Domino Sequence

A direct one-pot approach to polysubstituted indolizinones from tertiary propargylic alcohols using a palladium-catalyzed domino process involving aminopalladation, reductive elimination, and 1,2-shift is described.

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Veröffentlicht in:Organic letters 2010-06, Vol.12 (11), p.2500-2503
Hauptverfasser: Kim, Ikyon, Kim, Kyungsun
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes - chemistry
Catalysis
Combinatorial Chemistry Techniques
Cyclization
Indolizines - chemical synthesis
Indolizines - chemistry
Molecular Structure
Palladium - chemistry
Propanols - chemistry
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Zusammenfassung:A direct one-pot approach to polysubstituted indolizinones from tertiary propargylic alcohols using a palladium-catalyzed domino process involving aminopalladation, reductive elimination, and 1,2-shift is described.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol1006778