Challenges in the clinical application of whole-genome sequencing

Since whole-genome sequencing will show that every patient has an above-average risk for some disorders, and for having children with some genetic diseases, every patient could face some negative social consequences from those risks, whether in insurance, employment, stigma, or otherwise. [...] specific sequencing methods will have limitations that need to be understood. [...] interpretation of a whole-genome sequence requires good information about every known genetic disease and pharmacological risk.