Stereoselective One-Pot Synthesis of 1-Aminoindanes and 5,6-Fused Azacycles Using a Gold-Catalyzed Redox-Pinacol-Mannich-Michael Cascade

Stereoselective One-Pot Synthesis of 1-Aminoindanes and 5,6-Fused Azacycles Using a Gold-Catalyzed Redox-Pinacol-Mannich-Michael Cascade

Just another Mannich Monday: A cascade intramolecular redox‐pinacol‐Mannich‐Michael reaction sequence catalyzed by gold complexes can be used to generate a variety of structures including spirocycles, 1‐aminoindanes, and 5,6‐fused azabicycles that have a quaternary carbon center. The reaction is cha...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie (International ed.) 2010-02, Vol.49 (9), p.1611-1614
Hauptverfasser: Yeom, Hyun-Suk, Lee, Youngun, Jeong, Jaewon, So, Eunsoo, Hwang, Soojin, Lee, Ji-Eun, Lee, Shim Sung, Shin, Seunghoon
Format: Artikel
Sprache:eng
Schlagworte:
carbenoids
cascade reactions
gold
Mannich reactions
redox chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Just another Mannich Monday: A cascade intramolecular redox‐pinacol‐Mannich‐Michael reaction sequence catalyzed by gold complexes can be used to generate a variety of structures including spirocycles, 1‐aminoindanes, and 5,6‐fused azabicycles that have a quaternary carbon center. The reaction is characterized by complete atom‐economy, high diastereoselectivity, and remarkable efficiency through tandem reactions.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200906346