Salt supplementation blunts the blood pressure response to telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes

Aims/hypothesis We assessed the effects of sodium chloride (NaCl) supplementation on the blood pressure response to treatment with telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes and habitually high (HDS, sodium excretion >200 mmol/24 h on two out of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Diabetologia 2010-07, Vol.53 (7), p.1295-1303
Hauptverfasser:	Ekinci, E. I, Thomas, G, MacIsaac, R. J, Johnson, C, Houlihan, C, Panagiotopoulos, S, Premaratne, E, Hao, H, Finch, S, O'Callaghan, C, Jerums, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin receptor blockade Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Antihypertensives Arterial hypertension. Arterial hypotension Benzimidazoles - pharmacology Benzimidazoles - therapeutic use Benzoates - pharmacology Benzoates - therapeutic use Biological and medical sciences Blood and lymphatic vessels Blood pressure Blood Pressure - drug effects Cardiology. Vascular system Clinical trials Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Double-Blind Method Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Experimental diseases Female Human Physiology Humans Hydrochlorothiazide - pharmacology Hydrochlorothiazide - therapeutic use Hypertension Hypertension - drug therapy Internal Medicine Male Medical research Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged noninsulin-dependent diabetes mellitus Plasma renin activity Potassium Salt Sodium Sodium Chloride, Dietary - pharmacology Sodium Chloride, Dietary - therapeutic use Thiazide diuretic therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Aims/hypothesis We assessed the effects of sodium chloride (NaCl) supplementation on the blood pressure response to treatment with telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes and habitually high (HDS, sodium excretion >200 mmol/24 h on two out of three consecutive occasions) or low (LDS, sodium excretion
ISSN:	0012-186X 1432-0428
DOI:	10.1007/s00125-010-1711-2