Palladium-Assisted Routes to Nucleosides

Palladium-Assisted Routes to Nucleosides

Palladium cross-coupling reactions have found many potential applications in the syntheses of nucleoside analogues used in antiviral or anticancer chemotherapy. An overview of the strategies that have been employed to make nucleosides is presented, focusing especially on the use of palladium cross-c...

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Veröffentlicht in:Chemical reviews 2003-05, Vol.103 (5), p.1875-1916
Hauptverfasser: Agrofoglio, Luigi A, Gillaizeau, Isabelle, Saito, Yoshio
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Catalysis
Chemical reactions
Chemotherapy
Cyclization
Ligands
Metals
Nucleosides - chemical synthesis
Nucleosides - chemistry
Palladium - chemistry
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Zusammenfassung:Palladium cross-coupling reactions have found many potential applications in the syntheses of nucleoside analogues used in antiviral or anticancer chemotherapy. An overview of the strategies that have been employed to make nucleosides is presented, focusing especially on the use of palladium cross-coupling reactions and other palladium-assisted routes.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr010374q