The mutation frequency of 8-oxo-7,8-dihydroguanine (8-oxodG) situated in a multiply damaged site: comparison of a single and two closely opposed 8-oxodG in Escherichia coli

A multiply damaged site (MDS) is defined as ≥2 lesions within a distance of 10–15 base pairs (bp). MDS generated by ionizing radiation contain oxidative base damage, and in vitro studies have indicated that if the base damage is

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Bibliographische Detailangaben
Veröffentlicht in:	DNA repair 2003-06, Vol.2 (6), p.695-705
Hauptverfasser:	Malyarchuk, Svitlana, Youngblood, Reneau, Landry, April M., Quillin, Elizabeth, Harrison, Lynn
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Oxo-7,8-dihydroguanine Bacteriology Biological and medical sciences Clustered DNA lesions DNA Damage DNA repair DNA Replication Escherichia coli - genetics Escherichia coli - metabolism Fundamental and applied biological sciences. Psychology Genes, Reporter Genetics Guanine - analogs & derivatives Guanine - metabolism Ionizing radiation DNA damage Microbiology Molecular and cellular biology Molecular genetics Multiply damaged sites Mutagenesis. Repair Mutation
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Beschreibung
Zusammenfassung:	A multiply damaged site (MDS) is defined as ≥2 lesions within a distance of 10–15 base pairs (bp). MDS generated by ionizing radiation contain oxidative base damage, and in vitro studies have indicated that if the base damage is
ISSN:	1568-7864 1568-7856
DOI:	10.1016/S1568-7864(03)00040-5