Lovastatin But Not Enalapril Reduces Glomerular Injury in Dahl Salt-Sensitive Rats

Dahl salt-sensitive (S) rats fed a high salt diet develop hypertension, hyperlipidemia, and progressive renal disease. Previous studies have suggested that lipids may be important in the pathogenesis of glomerulosclerosis in Dahl S rats. To investigate this possibility, Dahl S rats fed 4% NaCl chow...

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Veröffentlicht in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1992-11, Vol.20 (5), p.651-658
Hauptverfasser: OʼDonnell, Michael P, Kasiske, Bertram L, Katz, Stephen A, Schmitz, Paul G, Keane, William F
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Sprache:eng
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Zusammenfassung:Dahl salt-sensitive (S) rats fed a high salt diet develop hypertension, hyperlipidemia, and progressive renal disease. Previous studies have suggested that lipids may be important in the pathogenesis of glomerulosclerosis in Dahl S rats. To investigate this possibility, Dahl S rats fed 4% NaCl chow were treated chronically with the cholesterol synthesis inhibitor lovastatin. After 22 weeks, lovastatin-treated rats had a 38% reduction in serum cholesterol, a 76% reduction in urine albumin excretion, and one-sixth the incidence of focal glomerulosclerosis compared with vehicle-treated control rats. Blood pressure in lovastatin-treated rats was significantly (p
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.20.5.651