Histocompatibility Antigens Associated with Behcet's Disease in Northern Han Chinese

Among Han nationality Chinese and living in the northern area of the Yellow River, 120 patients suffering from Behcet's disease and 100 unrelated healthy individuals were typed for histocompatibility antigens (HLA)-A, -B, -C, and -DR and -DQ antigens. HLA-DR and DQ typing was performed on B-lym...

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Veröffentlicht in:	Internal Medicine 1992, Vol.31(9), pp.1073-1075
Hauptverfasser:	MINESHITA, Satoru, TIAN, Ding, WANG, Li-man, JIAN, Xiu-Yi, LI, Shi-Yin, FANG, Gao-Zhang, BIAN, Tian-Yu, LIAO, Hai-Sun, TSUCHIDA, Mitsuru, TANAKA, Heizo, SAKUMA, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Behcet Syndrome - ethnology Behcet Syndrome - genetics Behcet Syndrome - immunology Behcet's disease Chi-Square Distribution China Chinese Complement C4a - analysis Complement C4b - analysis Electrophoresis, Agar Gel Female Gene Frequency HLA HLA Antigens - blood HLA-B Antigens - blood HLA-B51 Antigen HLA-C Antigens - blood Humans Immunodiffusion Immunogenetics Male Middle Aged Risk
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Zusammenfassung:	Among Han nationality Chinese and living in the northern area of the Yellow River, 120 patients suffering from Behcet's disease and 100 unrelated healthy individuals were typed for histocompatibility antigens (HLA)-A, -B, -C, and -DR and -DQ antigens. HLA-DR and DQ typing was performed on B-lymphocyte separated with Lympho-B-Kwik. The HLA-antisera were provided by 11th IHWC. Bf alleles and C4 allotypes were determined by immunofixation agarose-gel electrophoresis. HLA-B51 was found in 67/120 (55.83%) patients and in 12/100 (12%) controls, the Chi-square and relative risk values were 45.54 and 9.27, respectively (p
ISSN:	0918-2918 1349-7235
DOI:	10.2169/internalmedicine.31.1073