Risk Factors, biochemical markers, and genetic polymorphisms in early coronary artery disease

To assess the risk factors, lipid and apolipoprotein profile, hemostasis variables, and polymorphisms of the apolipoprotein AI-CIII gene in early coronary artery disease (CAD). Case-control study with 112 patients in each group controlled by sex and age. After clinical evaluation and nutritional ins...

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Veröffentlicht in:Arquivos brasileiros de cardiologia 2003-04, Vol.80 (4), p.379-395
Hauptverfasser: Izar, Maria Cristina, Fonseca, Francisco Antonio Helfenstein, Ihara, Sílvia Saiuli Miki, Kasinski, Nelson, Sang, Won Han, Lopes, Ieda Edite Lanzarini, Pinto, Leonor do Espírito Santo de Almeida, Relvas, Waldir Gabriel Miranda, Lourenço, Daisy, Tufik, Sérgio, de Paola, Angelo Amato Vincenzo, Carvalho, Antonio Carlos Camargo
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container_issue 4
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container_title Arquivos brasileiros de cardiologia
container_volume 80
creator Izar, Maria Cristina
Fonseca, Francisco Antonio Helfenstein
Ihara, Sílvia Saiuli Miki
Kasinski, Nelson
Sang, Won Han
Lopes, Ieda Edite Lanzarini
Pinto, Leonor do Espírito Santo de Almeida
Relvas, Waldir Gabriel Miranda
Lourenço, Daisy
Tufik, Sérgio
de Paola, Angelo Amato Vincenzo
Carvalho, Antonio Carlos Camargo
description To assess the risk factors, lipid and apolipoprotein profile, hemostasis variables, and polymorphisms of the apolipoprotein AI-CIII gene in early coronary artery disease (CAD). Case-control study with 112 patients in each group controlled by sex and age. After clinical evaluation and nutritional instruction, blood samples were collected for biochemical assays and genetic study. Familial history of early CAD (64 vs 39%), arterial hypertension (69 vs 36%), diabetes mellitus (25 vs 3%), and previous smoking (71 vs 46%) were more prevalent in the case group (p
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Case-control study with 112 patients in each group controlled by sex and age. After clinical evaluation and nutritional instruction, blood samples were collected for biochemical assays and genetic study. Familial history of early CAD (64 vs 39%), arterial hypertension (69 vs 36%), diabetes mellitus (25 vs 3%), and previous smoking (71 vs 46%) were more prevalent in the case group (p&lt;0.001). Hypertension and diabetes were independent risk factors. Early CAD was characterized by higher serum levels of total cholesterol (235 +/-6 vs 209 +/- 4 mg/dL), of LDL-c (154 +/- 5 vs 135 +/- 4 mg/dL), triglycerides (205 +/- 12 vs 143 +/- 9 mg/dL), and apolipoprotein B (129 +/- 3 vs 105 +/- 3 mg/dL), and lower serum levels of HDL-c (40 +/- 1 vs 46 +/- 1 mg/dL) and apolipoprotein AI (134 +/- 2 vs 146 +/- 2mg/dL) [p&lt;0.01], in addition to an elevation in fibrinogen and D-dimer (p&lt;0.02). The simultaneous presence of the rare alleles of the APO AI-CIII genes in early CAD are associated with hypertriglyceridemia (p=0.03). Of the classical risk factors, hypertension and diabetes mellitus were independently associated with early CAD. In addition to an unfavorable lipid profile, an increase in the thrombotic risk was identified in this population. 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The simultaneous presence of the rare alleles of the APO AI-CIII genes in early CAD are associated with hypertriglyceridemia (p=0.03). Of the classical risk factors, hypertension and diabetes mellitus were independently associated with early CAD. In addition to an unfavorable lipid profile, an increase in the thrombotic risk was identified in this population. 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subjects Adult
Apolipoprotein A-I - genetics
Apolipoprotein C-III
Apolipoproteins C - genetics
Biomarkers - blood
Case-Control Studies
Coronary Artery Disease - blood
Coronary Artery Disease - etiology
Coronary Artery Disease - genetics
Female
Hemostasis
Humans
Lipids - blood
Male
Middle Aged
Polymorphism, Genetic
Risk Factors
title Risk Factors, biochemical markers, and genetic polymorphisms in early coronary artery disease
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