Characteristics of the T cell-mediated immune response to maedi-visna virus

Virus-specific T cell-mediated immunity was investigated in healthy sheep persistently infected with the ruminant lentivirus maedi-visna. Visna-specific lymphocyte proliferation was demonstrated in response to both purified virions and recombinant p25, the major core protein of maedi-visna virus. Th...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1992-12, Vol.191 (2), p.1009-1012
Hauptverfasser:	Reyburn, H.T., Roy, D.J., Blacklaws, B.A., Sargan, D.R., Watt, N.J., McConnell, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences CD4-Positive T-Lymphocytes - immunology CD8 Antigens - immunology Fundamental and applied biological sciences. Psychology Immunity, Cellular Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Maedi-Visna virus Microbiology Pneumonia, Progressive Interstitial, of Sheep - immunology Recombinant Proteins - immunology Recombinant Proteins - pharmacology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Sheep T-Lymphocytes - immunology Viral Core Proteins - immunology Viral Core Proteins - pharmacology Virion - immunology Virology
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Beschreibung
Zusammenfassung:	Virus-specific T cell-mediated immunity was investigated in healthy sheep persistently infected with the ruminant lentivirus maedi-visna. Visna-specific lymphocyte proliferation was demonstrated in response to both purified virions and recombinant p25, the major core protein of maedi-visna virus. The responding T cell population in this assay was mainly of the CD4 + phenotype, although in some individuals CD8+ T cells were also shown to respond to visna antigen in this system.
ISSN:	0042-6822 1096-0341
DOI:	10.1016/0042-6822(92)90282-T