The effect of a contralateral contraction on maximal voluntary activation and central fatigue in elbow flexor muscles

A long-duration, submaximal contraction of a hand muscle increases central fatigue during a subsequent contraction in the other hand. However, this 'cross-over' of central fatigue between limbs is small and the location within the central nervous system at which this effect occurs is unknown. We investigated this 'cross-over' by measurement of the force and EMG responses to transcranial magnetic stimulation of the motor cortex (TMS). To produce central fatigue, we used sustained maximal voluntary contractions (MVCs). In the first study, subjects (n=10) performed four 1-min sustained MVCs of the elbow flexors, alternating between the left and right arms (two MVCs per arm). The sustained MVCs were performed consecutively with no rest periods. In the second study, the same subjects made two sustained 1-min MVCs with the same arm with a 1-min rest between efforts. During each sustained MVC, a series of TMS and brachial plexus stimuli were delivered. Surface EMG was recorded from biceps brachii and brachioradialis muscles bilaterally. Voluntary activation was estimated during each MVC using measurement of the force increments to TMS. On average during each sustained MVC, voluntary activation declined by 7-12% (absolute change, P