Proinflammatory cytokines and their role in the development of major transplant-related complications in the early phase after allogeneic bone marrow transplantation

Serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor (TNF)-alpha were frequently measured during the first 30 days after allogeneic bone marrow transplantation (BMT) in 84 consecutive adult patients. Major transplant-related complications (MTCs) occurred in 33% of cas...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia 2003-06, Vol.17 (6), p.1150-1156
Hauptverfasser:	SCHOTS, R, KAUFMAN, L, VAN RIET, I, BEN OTHMAN, T, DE WAELE, M, VAN CAMP, B, DEMANET, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Bacteremia - blood Bacteremia - etiology Bacteremia - pathology Biological and medical sciences Bone marrow Bone marrow transplantation Bone Marrow Transplantation - adverse effects Bone marrow, stem cells transplantation. Graft versus host reaction Bone tumors C-reactive protein C-Reactive Protein - analysis Capillary Leak Syndrome - blood Capillary Leak Syndrome - etiology Capillary Leak Syndrome - pathology Complications Cytokines Female Graft versus host disease Graft vs Host Disease - blood Graft vs Host Disease - etiology Graft vs Host Disease - pathology Graft-versus-host reaction Hepatic Veno-Occlusive Disease - blood Hepatic Veno-Occlusive Disease - etiology Hepatic Veno-Occlusive Disease - pathology Humans Idiopathic pneumonia syndrome Inflammation Interleukin 6 Interleukin 8 Interleukin-6 - blood Interleukin-8 - blood Leukemia Leukemia - blood Leukemia - therapy Liver diseases Male Medical sciences Mortality Multivariate analysis Myelodysplastic syndromes Neural Tube Defects - therapy Pathogenesis Patients Pneumonia Pneumonia - blood Pneumonia - etiology Pneumonia - pathology Proteins Risk Factors Serum levels Stem cell transplantation Toxicity Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Conditioning - adverse effects Transplantation, Homologous Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor (TNF)-alpha were frequently measured during the first 30 days after allogeneic bone marrow transplantation (BMT) in 84 consecutive adult patients. Major transplant-related complications (MTCs) occurred in 33% of cases and included veno-occlusive liver disease, idiopathic pneumonia syndrome, severe endothelial leakage syndrome and >grade II acute graft-versus-host disease. Compared with patients having minor complications, those with MTCs developed higher levels at times of maximal clinical signs (all cytokines, P
ISSN:	0887-6924 1476-5551
DOI:	10.1038/sj.leu.2402946