Relative efficacy of melarsen oxide compared with mel Cy (Cymelarsan ®) when used in combination with difluoromethylornithine in the treatment of trypanosomiasis of the central nervous system

A comparison was made between the efficacy of mel Cy (Cymelarsan ®) and melarsen oxide to cure central nervous system trypanosomiasis in a chronic Trypanosoma brucei mouse model. Combination treatment with difluoromethylornithine and arsenical was used and it was found that there was only a marginal...

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Veröffentlicht in:	Transactions of the Royal Society of Tropical Medicine and Hygiene 1992-05, Vol.86 (3), p.257-258
1. Verfasser:	Jennings, F.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenicals - therapeutic use Central Nervous System Diseases - drug therapy Drug Therapy, Combination Eflornithine - therapeutic use Mice Models, Biological Trypanocidal Agents - therapeutic use Trypanosoma brucei Trypanosomiasis, African - drug therapy
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Beschreibung
Zusammenfassung:	A comparison was made between the efficacy of mel Cy (Cymelarsan ®) and melarsen oxide to cure central nervous system trypanosomiasis in a chronic Trypanosoma brucei mouse model. Combination treatment with difluoromethylornithine and arsenical was used and it was found that there was only a marginal advantage in using the water-soluble mel Cy in terms of the numbers of mice cured.
ISSN:	0035-9203 1878-3503
DOI:	10.1016/0035-9203(92)90300-2