REVEROMYCINS, NEW INHIBITORS OF EUKARYOTIC CELL GROWTH: III. STRUCTURES OF REVEROMYCINS A, B, C AND D

Reveromycins A, B, C and D are new group inhibitors of the mitogenic activity of epidermal growth factor (EGF), produced by Streptomyces sp. Reveromycins are novel polyketide type antibiotics which have two terminal carboxylic groups, a spiroketal, a succinate and a varied side chain in the molecule...

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Veröffentlicht in:	Journal of antibiotics 1992/09/25, Vol.45(9), pp.1420-1427
Hauptverfasser:	KOSHINO, HIROYUKI, TAKAHASHI, HIDETOSHI, OSADA, HIROYUKI, ISONO, KIYOSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Anti-Bacterial Agents - chemistry Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Chemotherapic agents Chromatography, High Pressure Liquid Epidermal Growth Factor - antagonists & inhibitors Fundamental and applied biological sciences. Psychology Hydrolysis Magnetic Resonance Spectroscopy Methylation Microbiology Pyrans - chemistry Spiro Compounds - chemistry Streptomyces
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Beschreibung
Zusammenfassung:	Reveromycins A, B, C and D are new group inhibitors of the mitogenic activity of epidermal growth factor (EGF), produced by Streptomyces sp. Reveromycins are novel polyketide type antibiotics which have two terminal carboxylic groups, a spiroketal, a succinate and a varied side chain in the molecule. Determination of their structures by chemical and spectroscopic methods, in particular NMR studies, is described.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.45.1420