Prognostic value of GST-π expression in diffuse large B-cell lymphomas

Among mechanisms potentially involved in resistance to alkylating agents and anthracyclines, the glutathione system has been extensively studied in vitro . We analyzed by immunohistochemistry the relation between glutathione s-transferase π (GST- π ) expression in tumor cells and outcome in 69 cases...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia 2003-05, Vol.17 (5), p.972-977
Hauptverfasser:	Ribrag, V, Koscielny, S, Carpiuc, I, Cebotaru, C, Vande Walle, H, Talbot, M, Fenaux, P, Bosq, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating agents Alkylation Anthracycline Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use B-cell lymphoma Biological and medical sciences Cancer Research Chemotherapy Correlation Critical Care Medicine Female Follow-Up Studies Glutathione Glutathione S-Transferase pi Glutathione transferase Glutathione Transferase - metabolism Hematologic and hematopoietic diseases Hematology Humans Immunoenzyme Techniques Immunohistochemistry Intensive Internal Medicine Isoenzymes - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes B Lymphoma, B-Cell - drug therapy Lymphoma, B-Cell - enzymology Lymphoma, B-Cell - pathology Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - enzymology Lymphoma, Large B-Cell, Diffuse - pathology Male Medical sciences Medicine Medicine & Public Health Middle Aged Multivariate analysis Neoplasm Staging Oncology original-manuscript Pharmacology. Drug treatments Prognosis Prospective Studies Remission Survival Survival Rate Tumor cells Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Among mechanisms potentially involved in resistance to alkylating agents and anthracyclines, the glutathione system has been extensively studied in vitro . We analyzed by immunohistochemistry the relation between glutathione s-transferase π (GST- π ) expression in tumor cells and outcome in 69 cases of diffuse large B-cell NHL (DLBCL). GST- π expression was considered as low when
ISSN:	0887-6924 1476-5551
DOI:	10.1038/sj.leu.2402930