IGF-II mRNA expression in LI human glioblastoma cell line parallels cell growth

A human glioblastoma cell line was found to express in vitro mRNA transcripts specific for insulin-like growth factor-II (IGF-II) and growth-hormone releasing-hormone (GHRH). In the absence of gross morphological changes, retinoic acid reduced the growth rate without major change of IGF-II mRNA expr...

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Veröffentlicht in:	Neuroscience letters 1992-09, Vol.144 (1), p.25-28
Hauptverfasser:	Melino, Gennaro, Stephanou, Anastasis, Annicchiarico-Petruzzelli, Margherita, Finazzi-Agró, Alessandro, Knight, Richard A., Lightman, Stafford L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Northern Brain Neoplasms - metabolism Cell physiology Eflornithine - pharmacology Fundamental and applied biological sciences. Psychology Glioblastoma Glioma - metabolism Growth hormone-releasing hormone Growth Hormone-Releasing Hormone - metabolism Humans Insulin-Like Growth Factor II - biosynthesis Insulin-like growth factor-II Molecular and cellular biology Responses to growth factors, tumor promotors, other factors Retinoic acid RNA, Messenger - analysis RNA, Messenger - biosynthesis RNA, Messenger - isolation & purification RNA, Neoplasm - analysis RNA, Neoplasm - biosynthesis RNA, Neoplasm - isolation & purification Tretinoin - pharmacology Tumor Cells, Cultured α-Difluoromethylornithine
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Zusammenfassung:	A human glioblastoma cell line was found to express in vitro mRNA transcripts specific for insulin-like growth factor-II (IGF-II) and growth-hormone releasing-hormone (GHRH). In the absence of gross morphological changes, retinoic acid reduced the growth rate without major change of IGF-II mRNA expression, while α-difluoromethylornithine produced a complete growth arrest and a sharp decrease of IGF-II mRNA expression. Both reagents increased the expression of GHRH mRNA. Also in this glioblastoma cell line, like other neuroectodermal tumours, IGF-II mRNA is expressed independently from GHRH and seems to be parallel to growth rate.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(92)90707-E