Dissociation of neurocognitive deficits in a monozygotic twin pair concordant for schizophrenia

Cognitive impairment varies markedly among schizophrenic individuals, although the reason for this is unknown. A monozygotic twin pair concordant for schizophrenia was evaluated using electrophysiological and neurobehavioral measures. Each twin showed a distinctive pattern of deficits; furthermore,...

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Veröffentlicht in:	The journal of neuropsychiatry and clinical neurosciences 1992, Vol.4 (4), p.449-453
Hauptverfasser:	Condray, R, Steinhauer, S R, van Kammen, D P, Zubin, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cerebral Cortex - physiopathology Diseases in Twins - genetics Diseases in Twins - psychology Electroencephalography Evoked Potentials, Auditory - physiology Humans Male Neurocognitive Disorders - diagnosis Neurocognitive Disorders - genetics Neurocognitive Disorders - physiopathology Neurocognitive Disorders - psychology Neuropsychological Tests Psychiatric Status Rating Scales Schizophrenia - diagnosis Schizophrenia - genetics Schizophrenia - physiopathology Schizophrenic Psychology Twins, Monozygotic - genetics Twins, Monozygotic - psychology Wechsler Scales
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Zusammenfassung:	Cognitive impairment varies markedly among schizophrenic individuals, although the reason for this is unknown. A monozygotic twin pair concordant for schizophrenia was evaluated using electrophysiological and neurobehavioral measures. Each twin showed a distinctive pattern of deficits; furthermore, clinical course and electrophysiological activity were not consonant with social and neurobehavioral functioning. Results suggest complex interrelationships between neurocognitive functioning and clinical presentation in schizophrenia.
ISSN:	0895-0172 1545-7222
DOI:	10.1176/jnp.4.4.449