Intermolecular Enol Ether−Alkyne Metathesis

A new intermolecular metathesis between a variety of alkynes and alkyl enol ethers is described. The best results were obtained with the second generation Grubbs' precatalysts. The reaction occurred with a high degree of regioselectivity and provided electron-rich dienes, which underwent a vari...

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Veröffentlicht in:	Organic letters 2003-05, Vol.5 (10), p.1793-1796
Hauptverfasser:	Giessert, Anthony J, Snyder, Lee, Markham, Jordan, Diver, Steven T
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemical synthesis Cyclization Electrons Ethers - chemical synthesis Indicators and Reagents Magnetic Resonance Spectroscopy Ruthenium Compounds - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	A new intermolecular metathesis between a variety of alkynes and alkyl enol ethers is described. The best results were obtained with the second generation Grubbs' precatalysts. The reaction occurred with a high degree of regioselectivity and provided electron-rich dienes, which underwent a variety of [4 + 2] cycloadditions.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol034459k