White Cell Telomere Length and Risk of Premature Myocardial Infarction

OBJECTIVE—Biological age may be distinct from chronological age and contribute to the pathogenesis of age-related diseases. Mean telomeres lengths provide an assessment of biological age with shorter telomeres, indicating increased biological age. We investigated whether subjects with premature myoc...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2003-05, Vol.23 (5), p.842-846
Hauptverfasser:	Brouilette, Scott, Singh, Ravi K, Thompson, John R, Goodall, Alison H, Samani, Nilesh J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Aging - genetics Biological and medical sciences Cardiology. Vascular system Coronary Disease - epidemiology Coronary Disease - genetics Coronary heart disease England - epidemiology Female Heart Humans Leukocytes - ultrastructure Male Medical sciences Middle Aged Myocardial Infarction - epidemiology Myocardial Infarction - genetics Retrospective Studies Risk Risk Factors Telomere - ultrastructure
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Zusammenfassung:	OBJECTIVE—Biological age may be distinct from chronological age and contribute to the pathogenesis of age-related diseases. Mean telomeres lengths provide an assessment of biological age with shorter telomeres, indicating increased biological age. We investigated whether subjects with premature myocardial infarction (MI) had shorter leukocyte telomeres. METHODS AND RESULTS—Mean terminal restriction fragment (TRF) length, a measure of average telomere size, was compared in leukocyte DNA of 203 cases with a premature MI (
ISSN:	1079-5642 1524-4636
DOI:	10.1161/01.ATV.0000067426.96344.32