Oligosaccharide Synthesis on a Fluorous Support

Oligosaccharide Synthesis on a Fluorous Support

The fluorous support Hfb (see picture) enabled high‐yielding oligosaccharide syntheses in which the synthetic intermediates could be purified by simple fluorous–organic solvent extraction, and the reactions could be monitored spectroscopically and by TLC. Hfb was readily attached to the anomeric hyd...

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Veröffentlicht in:Angewandte Chemie International Edition 2003-05, Vol.42 (18), p.2047-2051
Hauptverfasser: Miura, Tsuyoshi, Goto, Kohtaro, Hosaka, Daisuke, Inazu, Toshiyuki
Format: Artikel
Sprache:eng
Schlagworte:
fluorine
Fluorocarbons - chemistry
Glycosides - chemistry
glycosylation
Molecular Structure
oligosaccharides
Oligosaccharides - chemical synthesis
Osmium Tetroxide - chemistry
synthetic methods
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Zusammenfassung:The fluorous support Hfb (see picture) enabled high‐yielding oligosaccharide syntheses in which the synthetic intermediates could be purified by simple fluorous–organic solvent extraction, and the reactions could be monitored spectroscopically and by TLC. Hfb was readily attached to the anomeric hydroxy group of a carbohydrate. The fluorous support could be removed in high yield, and was recyclable.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200250531