NEW METHOD OF DETECTING NITRIC OXIDE PRODUCTION
Nitric oxide (NO) reacts with H2O2 to produce a rise in potent luminol-dependent chemiluminescence under neutral pH conditions. We applied this reaction to the continuous detection of NO released from the rat isolated perfused kidney with simultaneous pressure changes. Acetylcholine increased NO rel...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1992/08/25, Vol.40(8), pp.2233-2235 |
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| container_end_page | 2235 |
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| container_issue | 8 |
| container_start_page | 2233 |
| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 40 |
| creator | KIKUCHI, Kazuya HAYAKAWA, Hiroshi NAGANO, Tetsuo HIRATA, Yasunobu SUGIMOTO, Tsuneaki HIROBE, Masaaki |
| description | Nitric oxide (NO) reacts with H2O2 to produce a rise in potent luminol-dependent chemiluminescence under neutral pH conditions. We applied this reaction to the continuous detection of NO released from the rat isolated perfused kidney with simultaneous pressure changes. Acetylcholine increased NO release dose-dependently with the pressure reduction. An NO synthesis inhibitor, NG-monomethyl-L-arginine, abolished the release. This inhibition was reversed by the addition of L-arginine. |
| doi_str_mv | 10.1248/cpb.40.2233 |
| format | Article |
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We applied this reaction to the continuous detection of NO released from the rat isolated perfused kidney with simultaneous pressure changes. Acetylcholine increased NO release dose-dependently with the pressure reduction. An NO synthesis inhibitor, NG-monomethyl-L-arginine, abolished the release. This inhibition was reversed by the addition of L-arginine.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.40.2233</identifier><identifier>PMID: 1423789</identifier><identifier>CODEN: CPBTAL</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Biological and medical sciences ; chemiluminescence ; Fundamental and applied biological sciences. 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Pharm. Bull.</addtitle><description>Nitric oxide (NO) reacts with H2O2 to produce a rise in potent luminol-dependent chemiluminescence under neutral pH conditions. We applied this reaction to the continuous detection of NO released from the rat isolated perfused kidney with simultaneous pressure changes. Acetylcholine increased NO release dose-dependently with the pressure reduction. An NO synthesis inhibitor, NG-monomethyl-L-arginine, abolished the release. This inhibition was reversed by the addition of L-arginine.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>chemiluminescence</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Kidney - metabolism</subject><subject>luminol</subject><subject>Male</subject><subject>nitric oxide</subject><subject>Nitric Oxide - analysis</subject><subject>Nitric Oxide - metabolism</subject><subject>perfused rat kidney</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vertebrates: urinary system</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1PgzAYxhujmXN68mzCwXgxbP2ClqMBtpFMMAuL3prSFmVhH9Lt4H8vhGW79E37_PI8fR8AHhEcI0z5RO2LMYVjjAm5AkNEKHO99nINhhDCwMXEJ7fgzto1hNiDjAzAAFFMGA-GYJLGn857nM-zyMmmThTncZgn6cxJk3yZhE72lUSx87HMolX7nqX34KaUtTUPpzkCq2mch3N3kc2S8G3hKh-yg-ur0qMlZIoRCj2ItWTa17TgOEC8gFyiNl1qjrgueRAQrgnUmGpeIo-ZQJEReOl9983u92jsQWwqq0xdy63ZHa1gBLNuhxZ87UHV7KxtTCn2TbWRzZ9AUHT1iLYeQaHo6mnpp5PtsdgYfWH7Plr9-aRLq2RdNnKrKnvGqMfaz3Y2UY-t7UF-m7Mum0OlatNFosDjXezp6NIv8o9shNmSf8KYflA</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>KIKUCHI, Kazuya</creator><creator>HAYAKAWA, Hiroshi</creator><creator>NAGANO, Tetsuo</creator><creator>HIRATA, Yasunobu</creator><creator>SUGIMOTO, Tsuneaki</creator><creator>HIROBE, Masaaki</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>NEW METHOD OF DETECTING NITRIC OXIDE PRODUCTION</title><author>KIKUCHI, Kazuya ; HAYAKAWA, Hiroshi ; NAGANO, Tetsuo ; HIRATA, Yasunobu ; SUGIMOTO, Tsuneaki ; HIROBE, Masaaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c607t-6cf54f07c7340502da7d6d4b82918b08a1789ad818df89938d30d24d8f157e9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>chemiluminescence</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>Kidney - metabolism</topic><topic>luminol</topic><topic>Male</topic><topic>nitric oxide</topic><topic>Nitric Oxide - analysis</topic><topic>Nitric Oxide - metabolism</topic><topic>perfused rat kidney</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vertebrates: urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIKUCHI, Kazuya</creatorcontrib><creatorcontrib>HAYAKAWA, Hiroshi</creatorcontrib><creatorcontrib>NAGANO, Tetsuo</creatorcontrib><creatorcontrib>HIRATA, Yasunobu</creatorcontrib><creatorcontrib>SUGIMOTO, Tsuneaki</creatorcontrib><creatorcontrib>HIROBE, Masaaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIKUCHI, Kazuya</au><au>HAYAKAWA, Hiroshi</au><au>NAGANO, Tetsuo</au><au>HIRATA, Yasunobu</au><au>SUGIMOTO, Tsuneaki</au><au>HIROBE, Masaaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NEW METHOD OF DETECTING NITRIC OXIDE PRODUCTION</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1992</date><risdate>1992</risdate><volume>40</volume><issue>8</issue><spage>2233</spage><epage>2235</epage><pages>2233-2235</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>Nitric oxide (NO) reacts with H2O2 to produce a rise in potent luminol-dependent chemiluminescence under neutral pH conditions. We applied this reaction to the continuous detection of NO released from the rat isolated perfused kidney with simultaneous pressure changes. Acetylcholine increased NO release dose-dependently with the pressure reduction. An NO synthesis inhibitor, NG-monomethyl-L-arginine, abolished the release. This inhibition was reversed by the addition of L-arginine.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>1423789</pmid><doi>10.1248/cpb.40.2233</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1992/08/25, Vol.40(8), pp.2233-2235 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73274237 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological and medical sciences chemiluminescence Fundamental and applied biological sciences. Psychology In Vitro Techniques Kidney - metabolism luminol Male nitric oxide Nitric Oxide - analysis Nitric Oxide - metabolism perfused rat kidney Rats Rats, Wistar Vertebrates: urinary system |
| title | NEW METHOD OF DETECTING NITRIC OXIDE PRODUCTION |
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