Studies on Thermophile Products. IV. Structural Elucidation of Cytotoxic Substance, BS-1, Derived from Bacillus stearothermophilus

A new cytotoxic substance designated as BS-1 was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563. On the basis of spectral data, the structure of BS-1 was determined as bis(2-hydroxyethyl) trisulfide and confirmed by direct comparison with the synthetic compoun...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical & pharmaceutical bulletin 1992/08/25, Vol.40(8), pp.2210-2211
Hauptverfasser:	KOHAMA, Yasuhiro, IIDA, Kentaro, SEMBA, Taro, MIMURA, Tsutomu, INADA, Akira, TANAKA, Keishi, NAKANISHI, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - analysis Antineoplastic Agents - pharmacology B. stearothermophilus Biological and medical sciences bis(2-hydroxyethyl) trisulfide cytotoxicity Ethanol - analogs & derivatives Ethanol - analysis Ethanol - pharmacology General aspects Geobacillus stearothermophilus - chemistry leukemia lymphoma mastocytoma Medical sciences Pharmacology. Drug treatments structure Sulfides - analysis Sulfides - pharmacology Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A new cytotoxic substance designated as BS-1 was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563. On the basis of spectral data, the structure of BS-1 was determined as bis(2-hydroxyethyl) trisulfide and confirmed by direct comparison with the synthetic compound. BS-1 exhibited potent cytotoxicity against leukemia P388-D1, leukemia P388, mastocytoma P815, lymphoma EL4 and lymphoma MOLT4.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.40.2210