Determinants of left ventricular preload-adjusted maximal power
1 Hydraulics Laboratory, Institute Biomedical Technology, Ghent University, 9000 Gent; 2 Hemodynamic Research Center, University of Liege, 4000 Liege; and 3 Centre for Experimental Surgery and Anaesthesiology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium Maximal left ventricular (LV) hydr...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2003-06, Vol.284 (6), p.H2295-H2301 |
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| creator | Segers, Patrick Tchana-Sato, Vincent Leather, H. Alex Lambermont, Bernard Ghuysen, Alexandre Dogne, Jean-Michel Benoit, Patricia Morimont, Philippe Wouters, Patrick F Verdonck, Pascal Kolh, Philippe |
| description | 1 Hydraulics Laboratory, Institute Biomedical
Technology, Ghent University, 9000 Gent;
2 Hemodynamic Research Center, University of Liege, 4000 Liege; and 3 Centre for Experimental Surgery
and Anaesthesiology, Katholieke Universiteit Leuven, 3000 Leuven,
Belgium
Maximal left ventricular (LV)
hydraulic power output (PWR max ), corrected for preload as
PWR max /(V ed ) (where
V ed is the end-diastolic volume and is a constant
coefficient), is an index of LV contractility. Whereas
preload-adjusted maximal power (PAMP) is usually calculated with
= 2, there is uncertainty about the optimal value of ( = 1 for the normal LV and 2 for the dilated LV). The aim of
this work is to study the determining factors of . The data set
consisted of 245 recordings (steady state and vena cava occlusion) in
10 animals in an ischemic heart pig model. The occlusion data
yielded the slope ( E es ; 2.01 ± 0.77 mmHg/ml, range 0.71-4.16 mmHg/ml) and intercept (V 0 ;
11.9 ± 22.6 ml; range 76 to 39 ml) of the end-systolic
pressure-volume relation, and the optimal -factor (assessed by
fitting an exponential curve through the
V ed -PWR max relation) was 1.94 ± 0.88 (range 0.29-4.73). The relation of with V ed was
weak [ = 0.60 + 0.02(V ed );
r 2 = 0.20]. In contrast, we found an
excellent exponential relation between V 0 and [ = 2.16
r 2 = 0.70]. PAMP, calculated from the
steady-state data, was 0.64 ± 0.40 mW/ml 2 (range
0.14-2.83 mW/ml 2 ) with a poor correlation with
E es ( r = 0.30, P |
| doi_str_mv | 10.1152/ajpheart.01110.2002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73272768</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73272768</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-8418cd4206cc2d0262daab26d0eba74971a31c2ca62fe9529dd329ba5ea319c23</originalsourceid><addsrcrecordid>eNp1kMFu1DAQhi0EotvCEyChnLiltccbJxEHhAptkSpxKeeRY092vXLWwU7a7tvjkqVw4WRr_H-_xh9j7wQ_F6KCC70bt6TjdM6FyDPgHF6wVX6BUlSyfclWXCpZKiGrE3aa0o5zXtVKvmYnApSsZcVX7NMXmigObq_3UypCX3jqp-Ke9lN0ZvY6FmMkH7Qttd3NaSJbDPrRDdoXY3ig-Ia96rVP9PZ4nrEfV1_vLm_K2-_X3y4_35am4nIqm7VojF0DV8aA5aDAat2Bspw6Xa_bWmgpDBitoKe2gtZaCW2nK8rz1oA8Y2Lp9Y42hCF2Du8Bg3bLffYb1AY7QgDVoOQgMvNhYcYYfs6UJhxcMuS93lOYE9YSaqhVk4NyCZoYUorU4xjzF-MBBccn1_jHNf52jU-uM_X-WD93A9m_zFFuDnxcAlu32T64SDhuD8kFHzYHvJq9v6PH6bkamjUqvAFoKxxtn-mL_9PP-_xDyV9-VKMr</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73272768</pqid></control><display><type>article</type><title>Determinants of left ventricular preload-adjusted maximal power</title><source>MEDLINE</source><source>American Physiological Society</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Segers, Patrick ; Tchana-Sato, Vincent ; Leather, H. Alex ; Lambermont, Bernard ; Ghuysen, Alexandre ; Dogne, Jean-Michel ; Benoit, Patricia ; Morimont, Philippe ; Wouters, Patrick F ; Verdonck, Pascal ; Kolh, Philippe</creator><creatorcontrib>Segers, Patrick ; Tchana-Sato, Vincent ; Leather, H. Alex ; Lambermont, Bernard ; Ghuysen, Alexandre ; Dogne, Jean-Michel ; Benoit, Patricia ; Morimont, Philippe ; Wouters, Patrick F ; Verdonck, Pascal ; Kolh, Philippe</creatorcontrib><description>1 Hydraulics Laboratory, Institute Biomedical
Technology, Ghent University, 9000 Gent;
2 Hemodynamic Research Center, University of Liege, 4000 Liege; and 3 Centre for Experimental Surgery
and Anaesthesiology, Katholieke Universiteit Leuven, 3000 Leuven,
Belgium
Maximal left ventricular (LV)
hydraulic power output (PWR max ), corrected for preload as
PWR max /(V ed ) (where
V ed is the end-diastolic volume and is a constant
coefficient), is an index of LV contractility. Whereas
preload-adjusted maximal power (PAMP) is usually calculated with
= 2, there is uncertainty about the optimal value of ( = 1 for the normal LV and 2 for the dilated LV). The aim of
this work is to study the determining factors of . The data set
consisted of 245 recordings (steady state and vena cava occlusion) in
10 animals in an ischemic heart pig model. The occlusion data
yielded the slope ( E es ; 2.01 ± 0.77 mmHg/ml, range 0.71-4.16 mmHg/ml) and intercept (V 0 ;
11.9 ± 22.6 ml; range 76 to 39 ml) of the end-systolic
pressure-volume relation, and the optimal -factor (assessed by
fitting an exponential curve through the
V ed -PWR max relation) was 1.94 ± 0.88 (range 0.29-4.73). The relation of with V ed was
weak [ = 0.60 + 0.02(V ed );
r 2 = 0.20]. In contrast, we found an
excellent exponential relation between V 0 and [ = 2.16
r 2 = 0.70]. PAMP, calculated from the
steady-state data, was 0.64 ± 0.40 mW/ml 2 (range
0.14-2.83 mW/ml 2 ) with a poor correlation with
E es ( r = 0.30, P < 0.001). An alternative formulation of PAMP as
PWR max /(V ed V 0 ) 2 , incorporating V 0 , yielded
0.47 ± 0.26 mW/ml 2 (range 0.09-1.42
mW/ml 2 ) and was highly correlated with
E es ( r = 0.89, P < 0.001). In conclusion, correct preload adjustment of maximal LV
power requires incorporation of V 0 and thus of data
measured under altered loading conditions.
hemodynamics; ventricular function; blood flow; blood
pressure; contractile function</description><identifier>ISSN: 0363-6135</identifier><identifier>ISSN: 1522-1539</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.01110.2002</identifier><identifier>PMID: 12637350</identifier><language>eng</language><publisher>United States: Amer Physiological Soc</publisher><subject>Anatomie (cytologie, histologie, embryologie...) & physiologie ; Anatomy (cytology, histology, embryology...) & physiology ; Animals ; Arteries - physiology ; blood flow ; blood pressure ; Blood Pressure - physiology ; Cardiac Output - physiology ; Cardiovascular & respiratory systems ; contractile function ; Elasticity ; Energy Metabolism - physiology ; Female ; Heart Rate - physiology ; hemodynamics ; Human health sciences ; Hypertrophy, Left Ventricular - physiopathology ; Life sciences ; Male ; Myocardial Contraction - physiology ; Sciences de la santé humaine ; Sciences du vivant ; Stroke Volume - physiology ; Swine ; Systèmes cardiovasculaire & respiratoire ; Vascular Resistance - physiology ; ventricular function ; Ventricular Function, Left - physiology</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2003-06, Vol.284 (6), p.H2295-H2301</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-8418cd4206cc2d0262daab26d0eba74971a31c2ca62fe9529dd329ba5ea319c23</citedby><cites>FETCH-LOGICAL-c503t-8418cd4206cc2d0262daab26d0eba74971a31c2ca62fe9529dd329ba5ea319c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12637350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Segers, Patrick</creatorcontrib><creatorcontrib>Tchana-Sato, Vincent</creatorcontrib><creatorcontrib>Leather, H. Alex</creatorcontrib><creatorcontrib>Lambermont, Bernard</creatorcontrib><creatorcontrib>Ghuysen, Alexandre</creatorcontrib><creatorcontrib>Dogne, Jean-Michel</creatorcontrib><creatorcontrib>Benoit, Patricia</creatorcontrib><creatorcontrib>Morimont, Philippe</creatorcontrib><creatorcontrib>Wouters, Patrick F</creatorcontrib><creatorcontrib>Verdonck, Pascal</creatorcontrib><creatorcontrib>Kolh, Philippe</creatorcontrib><title>Determinants of left ventricular preload-adjusted maximal power</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>1 Hydraulics Laboratory, Institute Biomedical
Technology, Ghent University, 9000 Gent;
2 Hemodynamic Research Center, University of Liege, 4000 Liege; and 3 Centre for Experimental Surgery
and Anaesthesiology, Katholieke Universiteit Leuven, 3000 Leuven,
Belgium
Maximal left ventricular (LV)
hydraulic power output (PWR max ), corrected for preload as
PWR max /(V ed ) (where
V ed is the end-diastolic volume and is a constant
coefficient), is an index of LV contractility. Whereas
preload-adjusted maximal power (PAMP) is usually calculated with
= 2, there is uncertainty about the optimal value of ( = 1 for the normal LV and 2 for the dilated LV). The aim of
this work is to study the determining factors of . The data set
consisted of 245 recordings (steady state and vena cava occlusion) in
10 animals in an ischemic heart pig model. The occlusion data
yielded the slope ( E es ; 2.01 ± 0.77 mmHg/ml, range 0.71-4.16 mmHg/ml) and intercept (V 0 ;
11.9 ± 22.6 ml; range 76 to 39 ml) of the end-systolic
pressure-volume relation, and the optimal -factor (assessed by
fitting an exponential curve through the
V ed -PWR max relation) was 1.94 ± 0.88 (range 0.29-4.73). The relation of with V ed was
weak [ = 0.60 + 0.02(V ed );
r 2 = 0.20]. In contrast, we found an
excellent exponential relation between V 0 and [ = 2.16
r 2 = 0.70]. PAMP, calculated from the
steady-state data, was 0.64 ± 0.40 mW/ml 2 (range
0.14-2.83 mW/ml 2 ) with a poor correlation with
E es ( r = 0.30, P < 0.001). An alternative formulation of PAMP as
PWR max /(V ed V 0 ) 2 , incorporating V 0 , yielded
0.47 ± 0.26 mW/ml 2 (range 0.09-1.42
mW/ml 2 ) and was highly correlated with
E es ( r = 0.89, P < 0.001). In conclusion, correct preload adjustment of maximal LV
power requires incorporation of V 0 and thus of data
measured under altered loading conditions.
hemodynamics; ventricular function; blood flow; blood
pressure; contractile function</description><subject>Anatomie (cytologie, histologie, embryologie...) & physiologie</subject><subject>Anatomy (cytology, histology, embryology...) & physiology</subject><subject>Animals</subject><subject>Arteries - physiology</subject><subject>blood flow</subject><subject>blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Cardiac Output - physiology</subject><subject>Cardiovascular & respiratory systems</subject><subject>contractile function</subject><subject>Elasticity</subject><subject>Energy Metabolism - physiology</subject><subject>Female</subject><subject>Heart Rate - physiology</subject><subject>hemodynamics</subject><subject>Human health sciences</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Life sciences</subject><subject>Male</subject><subject>Myocardial Contraction - physiology</subject><subject>Sciences de la santé humaine</subject><subject>Sciences du vivant</subject><subject>Stroke Volume - physiology</subject><subject>Swine</subject><subject>Systèmes cardiovasculaire & respiratoire</subject><subject>Vascular Resistance - physiology</subject><subject>ventricular function</subject><subject>Ventricular Function, Left - physiology</subject><issn>0363-6135</issn><issn>1522-1539</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFu1DAQhi0EotvCEyChnLiltccbJxEHhAptkSpxKeeRY092vXLWwU7a7tvjkqVw4WRr_H-_xh9j7wQ_F6KCC70bt6TjdM6FyDPgHF6wVX6BUlSyfclWXCpZKiGrE3aa0o5zXtVKvmYnApSsZcVX7NMXmigObq_3UypCX3jqp-Ke9lN0ZvY6FmMkH7Qttd3NaSJbDPrRDdoXY3ig-Ia96rVP9PZ4nrEfV1_vLm_K2-_X3y4_35am4nIqm7VojF0DV8aA5aDAat2Bspw6Xa_bWmgpDBitoKe2gtZaCW2nK8rz1oA8Y2Lp9Y42hCF2Du8Bg3bLffYb1AY7QgDVoOQgMvNhYcYYfs6UJhxcMuS93lOYE9YSaqhVk4NyCZoYUorU4xjzF-MBBccn1_jHNf52jU-uM_X-WD93A9m_zFFuDnxcAlu32T64SDhuD8kFHzYHvJq9v6PH6bkamjUqvAFoKxxtn-mL_9PP-_xDyV9-VKMr</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Segers, Patrick</creator><creator>Tchana-Sato, Vincent</creator><creator>Leather, H. Alex</creator><creator>Lambermont, Bernard</creator><creator>Ghuysen, Alexandre</creator><creator>Dogne, Jean-Michel</creator><creator>Benoit, Patricia</creator><creator>Morimont, Philippe</creator><creator>Wouters, Patrick F</creator><creator>Verdonck, Pascal</creator><creator>Kolh, Philippe</creator><general>Amer Physiological Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>Q33</scope></search><sort><creationdate>20030601</creationdate><title>Determinants of left ventricular preload-adjusted maximal power</title><author>Segers, Patrick ; Tchana-Sato, Vincent ; Leather, H. Alex ; Lambermont, Bernard ; Ghuysen, Alexandre ; Dogne, Jean-Michel ; Benoit, Patricia ; Morimont, Philippe ; Wouters, Patrick F ; Verdonck, Pascal ; Kolh, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-8418cd4206cc2d0262daab26d0eba74971a31c2ca62fe9529dd329ba5ea319c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Anatomie (cytologie, histologie, embryologie...) & physiologie</topic><topic>Anatomy (cytology, histology, embryology...) & physiology</topic><topic>Animals</topic><topic>Arteries - physiology</topic><topic>blood flow</topic><topic>blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Cardiac Output - physiology</topic><topic>Cardiovascular & respiratory systems</topic><topic>contractile function</topic><topic>Elasticity</topic><topic>Energy Metabolism - physiology</topic><topic>Female</topic><topic>Heart Rate - physiology</topic><topic>hemodynamics</topic><topic>Human health sciences</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Life sciences</topic><topic>Male</topic><topic>Myocardial Contraction - physiology</topic><topic>Sciences de la santé humaine</topic><topic>Sciences du vivant</topic><topic>Stroke Volume - physiology</topic><topic>Swine</topic><topic>Systèmes cardiovasculaire & respiratoire</topic><topic>Vascular Resistance - physiology</topic><topic>ventricular function</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Segers, Patrick</creatorcontrib><creatorcontrib>Tchana-Sato, Vincent</creatorcontrib><creatorcontrib>Leather, H. Alex</creatorcontrib><creatorcontrib>Lambermont, Bernard</creatorcontrib><creatorcontrib>Ghuysen, Alexandre</creatorcontrib><creatorcontrib>Dogne, Jean-Michel</creatorcontrib><creatorcontrib>Benoit, Patricia</creatorcontrib><creatorcontrib>Morimont, Philippe</creatorcontrib><creatorcontrib>Wouters, Patrick F</creatorcontrib><creatorcontrib>Verdonck, Pascal</creatorcontrib><creatorcontrib>Kolh, Philippe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Segers, Patrick</au><au>Tchana-Sato, Vincent</au><au>Leather, H. Alex</au><au>Lambermont, Bernard</au><au>Ghuysen, Alexandre</au><au>Dogne, Jean-Michel</au><au>Benoit, Patricia</au><au>Morimont, Philippe</au><au>Wouters, Patrick F</au><au>Verdonck, Pascal</au><au>Kolh, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determinants of left ventricular preload-adjusted maximal power</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>284</volume><issue>6</issue><spage>H2295</spage><epage>H2301</epage><pages>H2295-H2301</pages><issn>0363-6135</issn><issn>1522-1539</issn><eissn>1522-1539</eissn><abstract>1 Hydraulics Laboratory, Institute Biomedical
Technology, Ghent University, 9000 Gent;
2 Hemodynamic Research Center, University of Liege, 4000 Liege; and 3 Centre for Experimental Surgery
and Anaesthesiology, Katholieke Universiteit Leuven, 3000 Leuven,
Belgium
Maximal left ventricular (LV)
hydraulic power output (PWR max ), corrected for preload as
PWR max /(V ed ) (where
V ed is the end-diastolic volume and is a constant
coefficient), is an index of LV contractility. Whereas
preload-adjusted maximal power (PAMP) is usually calculated with
= 2, there is uncertainty about the optimal value of ( = 1 for the normal LV and 2 for the dilated LV). The aim of
this work is to study the determining factors of . The data set
consisted of 245 recordings (steady state and vena cava occlusion) in
10 animals in an ischemic heart pig model. The occlusion data
yielded the slope ( E es ; 2.01 ± 0.77 mmHg/ml, range 0.71-4.16 mmHg/ml) and intercept (V 0 ;
11.9 ± 22.6 ml; range 76 to 39 ml) of the end-systolic
pressure-volume relation, and the optimal -factor (assessed by
fitting an exponential curve through the
V ed -PWR max relation) was 1.94 ± 0.88 (range 0.29-4.73). The relation of with V ed was
weak [ = 0.60 + 0.02(V ed );
r 2 = 0.20]. In contrast, we found an
excellent exponential relation between V 0 and [ = 2.16
r 2 = 0.70]. PAMP, calculated from the
steady-state data, was 0.64 ± 0.40 mW/ml 2 (range
0.14-2.83 mW/ml 2 ) with a poor correlation with
E es ( r = 0.30, P < 0.001). An alternative formulation of PAMP as
PWR max /(V ed V 0 ) 2 , incorporating V 0 , yielded
0.47 ± 0.26 mW/ml 2 (range 0.09-1.42
mW/ml 2 ) and was highly correlated with
E es ( r = 0.89, P < 0.001). In conclusion, correct preload adjustment of maximal LV
power requires incorporation of V 0 and thus of data
measured under altered loading conditions.
hemodynamics; ventricular function; blood flow; blood
pressure; contractile function</abstract><cop>United States</cop><pub>Amer Physiological Soc</pub><pmid>12637350</pmid><doi>10.1152/ajpheart.01110.2002</doi></addata></record> |
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| subjects | Anatomie (cytologie, histologie, embryologie...) & physiologie Anatomy (cytology, histology, embryology...) & physiology Animals Arteries - physiology blood flow blood pressure Blood Pressure - physiology Cardiac Output - physiology Cardiovascular & respiratory systems contractile function Elasticity Energy Metabolism - physiology Female Heart Rate - physiology hemodynamics Human health sciences Hypertrophy, Left Ventricular - physiopathology Life sciences Male Myocardial Contraction - physiology Sciences de la santé humaine Sciences du vivant Stroke Volume - physiology Swine Systèmes cardiovasculaire & respiratoire Vascular Resistance - physiology ventricular function Ventricular Function, Left - physiology |
| title | Determinants of left ventricular preload-adjusted maximal power |
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