Amino acid uptake regulation by cell growth in cultured hepatocytes isolated from fetal and adult rats

Amino acid uptake mediated by system A was studied in cultured fetal and adult hepatocytes, subjected to growth stimulation by EGF and insulin, or to growth inhibition by high cell density. The mitogenic stimulation induced a strong transport increase only in fetal cells, while the cell density-depe...

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Veröffentlicht in:	Bioscience reports 1992-04, Vol.12 (2), p.135-141
Hauptverfasser:	LEONI, S, SPAGNUOLO, S, MASSIMI, M, TERENZI, F, DEVIRGILIIS, L. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Amino Acids - metabolism Aminoisobutyric Acids - metabolism Animals Biological and medical sciences Biological Transport Cell Differentiation Cell Division - drug effects Cell Membrane - metabolism Cell physiology Cells, Cultured - drug effects DNA - biosynthesis Epidermal Growth Factor - pharmacology Fundamental and applied biological sciences. Psychology Gestational Age Humans Liver - drug effects Liver - growth & development Liver - metabolism Membrane and intracellular transports Molecular and cellular biology Rats Rats, Wistar
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Zusammenfassung:	Amino acid uptake mediated by system A was studied in cultured fetal and adult hepatocytes, subjected to growth stimulation by EGF and insulin, or to growth inhibition by high cell density. The mitogenic stimulation induced a strong transport increase only in fetal cells, while the cell density-dependent growth inhibition, probably mediated by molecules present on adult hepatocyte membranes, provoked the decrease of amino acid uptake only in the adult cells. The results indicate that the different modulation of amino acid transport by cell growth is dependent on the age and the differentiation stage of hepatocytes.
ISSN:	0144-8463 1573-4935
DOI:	10.1007/BF02351218