Detection of human papillomavirus in vulvar carcinoma. A study by in situ hybridisation

Fourty-four specimens of invasive cancers of the vulva, including 38 primary invasive squamous carcinomas, were analysed by in situ hybridisation with biotinylated HPV 6/11, 16 and 18 DNA probes. Four (9%) of the 44 carcinomas were positive for HPV DNA: three (7%) for HPV 16 DNA and one (2%) for HPV...

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Veröffentlicht in:	Archives of gynecology and obstetrics 1992-09, Vol.252 (1), p.31-35
Hauptverfasser:	Brandenberger, A W, Rüdlinger, R, Hänggi, W, Bersinger, N A, Dreher, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Carcinoma, Squamous Cell - pathology DNA Probes, HPV Female Humans Immunoenzyme Techniques Middle Aged Neoplasm Staging Papillomaviridae - isolation & purification Tumor Virus Infections - pathology Vulva - pathology Vulvar Neoplasms - pathology
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Zusammenfassung:	Fourty-four specimens of invasive cancers of the vulva, including 38 primary invasive squamous carcinomas, were analysed by in situ hybridisation with biotinylated HPV 6/11, 16 and 18 DNA probes. Four (9%) of the 44 carcinomas were positive for HPV DNA: three (7%) for HPV 16 DNA and one (2%) for HPV 6/11 DNA. HPV DNA was found only in squamous carcinomas. Of the 38 primary squamous carcinomas, 11% were positive (8% HPV 16, 3% HPV 6/11). The overall 5-year survival was 48.7%, 48.5% for the squamous carcinomas and 50.0% for the HPV DNA positive patients.
ISSN:	0932-0067 1432-0711
DOI:	10.1007/BF02389604