Effect of iontophoresis and fatty acids on permeation of Arginine Vasopressin through rat skin

The aim of this study was to assess the effects of fatty acids and iontophoretic mode of penetration enhancement on transdermal delivery of Arginine Vasopressin (AVP). Sprague–Dawley (SD) rat skin was pretreated with fatty acids (e.g. 5% w/v, lauric acid, oleic acid, and linoleic acid in ethanol:wat...

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Veröffentlicht in:	Pharmacological research 2003-06, Vol.47 (6), p.563-569
Hauptverfasser:	Nair, Vinod B, Panchagnula, Ramesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Analysis of Variance Animals Arginine Vasopressin - pharmacokinetics Fatty acids Fatty Acids - pharmacology Female FT-IR spectroscopy Iontophoresis Iontophoresis - methods Lauric Acids - pharmacology Linoleic Acid - pharmacology Lipid Bilayers Oleic Acid - pharmacology Permeability - drug effects Rats Rats, Sprague-Dawley Skin - drug effects Skin - metabolism Spectroscopy, Fourier Transform Infrared Transdermal delivery Vasopressin
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Beschreibung
Zusammenfassung:	The aim of this study was to assess the effects of fatty acids and iontophoretic mode of penetration enhancement on transdermal delivery of Arginine Vasopressin (AVP). Sprague–Dawley (SD) rat skin was pretreated with fatty acids (e.g. 5% w/v, lauric acid, oleic acid, and linoleic acid in ethanol:water (EtOH:W, 2:1 system) for 2 h and iontophoresis in vitro, separately or together. The results indicate that all fatty acids studied increased ( P
ISSN:	1043-6618 1096-1186
DOI:	10.1016/S1043-6618(03)00016-1