Unicolor and bicolor in situ hybridization in the diagnosis of peripheral neuroepithelioma and related tumors

The chromosome 22 breakpoint of the t(11;22) translocation of peripheral neuroepithelioma has been located, by fluorescence in situ hybridization, in the proximity of the interface between 22q12.1 and 22q12.2. Use of single cosmids or pools of cosmids of the flanking regions enables the monitoring o...

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Veröffentlicht in:	Genes chromosomes & cancer 1992-07, Vol.5 (1), p.30-34
Hauptverfasser:	Desmaze, C., Zucman, J., Delattre, O., Thomas, G., Aurias, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Neoplasms - diagnosis Bone Neoplasms - genetics Bone Neoplasms - pathology chromosome 11 chromosome 22 Chromosome Banding Chromosomes, Human, Pair 11 - ultrastructure Chromosomes, Human, Pair 22 - ultrastructure Color Cosmids diagnosis DNA Probes fluorescence in situ hybridization Genetic Markers Humans In Situ Hybridization, Fluorescence - methods man Neuroectodermal Tumors, Primitive, Peripheral - diagnosis Neuroectodermal Tumors, Primitive, Peripheral - genetics Neuroectodermal Tumors, Primitive, Peripheral - pathology neuroepithelioma Peripheral Nervous System Neoplasms - diagnosis Peripheral Nervous System Neoplasms - genetics Peripheral Nervous System Neoplasms - pathology Sarcoma, Ewing - diagnosis Sarcoma, Ewing - genetics Sarcoma, Ewing - pathology translocation Translocation, Genetic tumours
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Zusammenfassung:	The chromosome 22 breakpoint of the t(11;22) translocation of peripheral neuroepithelioma has been located, by fluorescence in situ hybridization, in the proximity of the interface between 22q12.1 and 22q12.2. Use of single cosmids or pools of cosmids of the flanking regions enables the monitoring of the translocation in interphase and in metaphase chromosomes. This method can now be routinely applied for the diagnosis of this translocation in mixed round cell tumors.
ISSN:	1045-2257 1098-2264
DOI:	10.1002/gcc.2870050105