Antibacterial activity of quinolone–Macrocycle conjugates

Novel quinolone–macrocycle conjugates displayed submicromolar antibacterial activity against Escherichia coli and Staphylococcus aureus bacterial strains. An analogous open-chain structure was not active at 100 μM against the same pathogenic strains. Novel quinolone–macrocycle conjugates displayed l...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-05, Vol.13 (10), p.1635-1638
Hauptverfasser:	Jefferson, Elizabeth A., Swayze, Eric E., Osgood, Stephen A., Miyaji, Alycia, Risen, Lisa M., Blyn, Lawrence B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Escherichia coli - drug effects Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacology Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Quinolones - chemistry Quinolones - pharmacology Staphylococcus aureus - drug effects Structure-Activity Relationship
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Zusammenfassung:	Novel quinolone–macrocycle conjugates displayed submicromolar antibacterial activity against Escherichia coli and Staphylococcus aureus bacterial strains. An analogous open-chain structure was not active at 100 μM against the same pathogenic strains. Novel quinolone–macrocycle conjugates displayed low to submicromolar MIC activity against Escherichia coli and Staphylococcus aureus bacterial strains.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(03)00285-3