Protein microarrays: Meeting analytical challenges for clinical applications

Protein microarrays: Meeting analytical challenges for clinical applications

Protein microarrays, one emerging class of proteomic technologies, have broad applications for discovery and quantitative analysis. A rapidly expanding use of this technology is the acquisition of information about the posttranslational modifications of proteins reflecting the activity state of sign...

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Veröffentlicht in:Cancer cell 2003-04, Vol.3 (4), p.317-325
Hauptverfasser: Liotta, Lance A, Espina, Virginia, Mehta, Arpita I, Calvert, Valerie, Rosenblatt, Kevin, Geho, David, Munson, Peter J, Young, Lynn, Wulfkuhle, Julia, Petricoin, Emanuel F
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antibodies
Biotechnology
Humans
Neoplasms - genetics
Neoplasms - therapy
Protein Array Analysis - methods
Proteome
Sensitivity and Specificity
Signal Transduction
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Beschreibung
Zusammenfassung:Protein microarrays, one emerging class of proteomic technologies, have broad applications for discovery and quantitative analysis. A rapidly expanding use of this technology is the acquisition of information about the posttranslational modifications of proteins reflecting the activity state of signal pathways and networks, and is now employed for the analysis of biopsy samples in clinical trial research.
ISSN:1535-6108
1878-3686
DOI:10.1016/S1535-6108(03)00086-2