Kinin generation following methacholine nasal airway challenge of non-allergic subjects

Kinin generation following methacholine nasal airway challenge of non-allergic subjects

Following nasal challenges with the muscarinic neurotransmitter methacholine in 14 patients with chronic non-allergic rhinitis, kinin generation was induced. This occurrence was inhibited by pretreatment with anticholinergic agents (ipratropium bromide) and by an overdose of neurotransmitter, indica...

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Veröffentlicht in:European archives of oto-rhino-laryngology 1992-10, Vol.249 (6), p.318-321
Hauptverfasser: BAUMGARTEN, C. R, NIEMZ, W, KUNKEL, G
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Biological and medical sciences
Chronic Disease
Female
Humans
Ipratropium - pharmacology
Kinins - biosynthesis
Male
Medical sciences
Methacholine Chloride - pharmacology
Middle Aged
Nasal Mucosa - metabolism
Nasal Provocation Tests
Non tumoral diseases
Otorhinolaryngology. Stomatology
Respiratory Hypersensitivity - metabolism
Rhinitis - metabolism
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Zusammenfassung:Following nasal challenges with the muscarinic neurotransmitter methacholine in 14 patients with chronic non-allergic rhinitis, kinin generation was induced. This occurrence was inhibited by pretreatment with anticholinergic agents (ipratropium bromide) and by an overdose of neurotransmitter, indicating that a muscarinic receptor is stimulating the liberation of kinin. These observations suggest that patients with chronic non-allergic rhinitis exhibit cholinergic neurotransmitter-induced kinin generation.
ISSN:0937-4477
1434-4726
DOI:10.1007/BF00179380