Effect of antisense oligonucleotide of noggin on spatial learning and memory of rats

To investigate the effect of antisense oligonucleotide (ASODN) of noggin on rat spatial learning and memory. Expression of noggin mRNA was measured by in situ hybridization method and the ability to spatial learning and memory was tested with Morris water maze. Compared with control rats, noggin mRN...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta pharmacologica Sinica 2003-05, Vol.24 (5), p.394-397
Hauptverfasser:	Fan, Xiao-Tang, Cai, Wen-Qin, Yang, Zhong, Xu, Hai-Wei, Zhang, Jin-Hai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins Female Hippocampus - drug effects Hippocampus - physiology Male Maze Learning - drug effects Memory - drug effects Neurons - metabolism Oligonucleotides, Antisense - pharmacology Proteins - antagonists & inhibitors Proteins - genetics Random Allocation Rats Rats, Wistar RNA, Messenger - genetics Space Perception - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	To investigate the effect of antisense oligonucleotide (ASODN) of noggin on rat spatial learning and memory. Expression of noggin mRNA was measured by in situ hybridization method and the ability to spatial learning and memory was tested with Morris water maze. Compared with control rats, noggin mRNA positive neurons in dentate gyrus (DG) and CA3 region of hippocampus were markedly increased after the Morris water maze training (P
ISSN:	1671-4083