Cyclo (His-Pro) potentiates GABA/ethanol-mediated chloride uptake by neurosynaptosomes

Cyclo (His-Pro) CHP is a cyclic dipeptide endogenous to the brain of a variety of animal species including man. Administration of exogenous peptide to rodents has been shown to exhibit a variety of biologic activities including, modification of pharmacologic actions of alcohol. Since there are many...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2003-03, Vol.24 (3), p.445-448
Hauptverfasser:	Imamura, Makoto, Prasad, Chandan
Format:	Artikel
Sprache:	eng
Schlagworte:	[formula omitted]-influx [formula omitted]-uptake Alcohol Alcoholism Animals Biological and medical sciences Biological Transport - drug effects Chlorides - metabolism Cyclo (His-Pro) Dose-Response Relationship, Drug Ethanol - pharmacology Fundamental and applied biological sciences. Psychology GABA gamma-Aminobutyric Acid - pharmacology Histidyl-proline diketopiperazine Male Peptides, Cyclic - pharmacology Piperazines - pharmacology Rats Rats, Sprague-Dawley Synaptosomes - drug effects Synaptosomes - metabolism
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Zusammenfassung:	Cyclo (His-Pro) CHP is a cyclic dipeptide endogenous to the brain of a variety of animal species including man. Administration of exogenous peptide to rodents has been shown to exhibit a variety of biologic activities including, modification of pharmacologic actions of alcohol. Since there are many apparent similarities between the actions of GABA and CHP in modulating alcohol pharmacology, we have examined whether CHP can modulate alcohol potentiation of GABA-receptor-mediated 36 Cl -influx in neurosynaptosomes. The results show a further dose-dependent potentiation of 36 Cl -influx in neurosynaptosomes by CHP in the presence of GABA and alcohol.
ISSN:	0196-9781 1873-5169
DOI:	10.1016/S0196-9781(03)00060-3