The effect of dexamethasone on neuropeptide y concentrations in specific hypothalamic regions

Neuropeptide Y (NPY) is a major hypothalamic peptide which is implicated in the regulation of energy balance and in the activation of the hypothalamo-pituitary adrenal axis. This study aimed primarily to determine the effects on regional hypothalamic NPY levels, of catabolism and weight loss induced...

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Veröffentlicht in:	Life sciences (1973) 1992, Vol.51 (16), p.1301-1307
Hauptverfasser:	McKibbin, Pauline E., Cotton, Stephen J., McCarthy, H.David, Williams, Gareth
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biochemistry and metabolism Biological and medical sciences Blood Glucose - metabolism Central nervous system Dexamethasone - pharmacology Fundamental and applied biological sciences. Psychology Hypothalamus - drug effects Hypothalamus - metabolism Insulin - blood Male Neuropeptide Y - drug effects Neuropeptide Y - metabolism Rats Rats, Wistar Vertebrates: nervous system and sense organs Weight Loss - drug effects
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Zusammenfassung:	Neuropeptide Y (NPY) is a major hypothalamic peptide which is implicated in the regulation of energy balance and in the activation of the hypothalamo-pituitary adrenal axis. This study aimed primarily to determine the effects on regional hypothalamic NPY levels, of catabolism and weight loss induced in rats by the synthetic glucocorticoid, dexamethasone, injected daily at a dose of 0.4 mg/kg for 7 days. NPY concentrations were significantly raised in the paraventricular nucleus (PVN) of male Wistar rats (45%, p=0.009; n=10) compared with saline-injected controls (n=10). Body weight (p
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(92)90020-P