Identification of 2-Aminobenzimidazole dimers as antibacterial agents

The preparation and evaluation of 2-aminobenzimidazole dimers as antibacterial agents is described. Biological screening of the dimers indicated that compounds with multiple chloro substituents possessed optimal antibacterial activity. The synthesis and evaluation of 2-aminobenzimidazole dimers as a...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-05, Vol.13 (10), p.1669-1672
Hauptverfasser:	Seth, Punit P, Jefferson, Elizabeth A, Risen, Lisa M, Osgood, Stephen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - pharmacology Biological and medical sciences Dimerization Enterococcus faecalis - drug effects Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Structure-Activity Relationship
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Zusammenfassung:	The preparation and evaluation of 2-aminobenzimidazole dimers as antibacterial agents is described. Biological screening of the dimers indicated that compounds with multiple chloro substituents possessed optimal antibacterial activity. The synthesis and evaluation of 2-aminobenzimidazole dimers as antibacterial agents is described.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(03)00245-2