Comparison of Insulin Regimens in Patients with Non-Insulin-Dependent Diabetes Mellitus

SOME patients with non-insulin-dependent diabetes mellitus (NIDDM) achieve good glycemic control when they are first treated with an oral hypoglycemic drug, but only approximately 50 percent continue to have satisfactory glycemic control after 10 years. 1 These patients are then often treated with insulin alone or in combination with an oral hypoglycemic drug, but the optimal mode of insulin administration remains controversial. The results of the available insulin-treatment studies in these patients are difficult to interpret for several reasons. First, the criteria for the selection of patients were variable, as was the duration of treatment. Second, the applicability of the proposed . . .