TDM35-a new monoclonal antibody to the XH1 cervical carcinoma cell line. Characterization and immunoperoxidase localization in benign and malignant tissues

The murine monoclonal IgG1 kappa antibody TDM35 was raised against the cervical carcinoma cell line XH1. The antibody recognizes 18.5–66 kDa NCA‐like glycoproteins and immunostains a variety of formalin‐fixed, paraffin‐embedded normal, benign, and malignant tissues. It is of value in the diagnosis o...

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Veröffentlicht in:	The Journal of pathology 1992-08, Vol.167 (4), p.391-397
Hauptverfasser:	Chana, Treena, Han, Xin, Dagg, Belinda, Lawrie, Andrew S., Gooding, Roger P., Eustace, Damian L. S., Fletcher, Christopher D. M., Heyderman, Eadie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnosis Animals Antibodies, Monoclonal - analysis Biological and medical sciences Carcinoma, Squamous Cell - diagnosis Electrophoresis, Polyacrylamide Gel Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Immunoglobulin G - immunology Immunoglobulin kappa-Chains - immunology Immunoperoxidase Lung Neoplasms - diagnosis Medical sciences Mice Mice, Inbred BALB C monoclonal antibody NCA-like Non tumoral diseases Pancreatic Neoplasms - diagnosis TDM35 Tumor Cells, Cultured - immunology tumour localization Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - immunology XH1 cell line
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Beschreibung
Zusammenfassung:	The murine monoclonal IgG1 kappa antibody TDM35 was raised against the cervical carcinoma cell line XH1. The antibody recognizes 18.5–66 kDa NCA‐like glycoproteins and immunostains a variety of formalin‐fixed, paraffin‐embedded normal, benign, and malignant tissues. It is of value in the diagnosis of carcinoma of the exocrine pancreas and it identifies foci of squamous and glandular differentiation in other tumours. TDM35 should form a useful addition to a panel of antibodies for the evaluation of epithelial lesions.
ISSN:	0022-3417 1096-9896
DOI:	10.1002/path.1711670408