Regulation of Vasopressin Receptors in Deoxycorticosterone Acetate–Salt Hypertension

Since arginine vasopressin may play a role in mlneralocorticoid hypertension, we examined the effects of deoxycorticosterone acetate (DOCA)-salt on vasopressin V1 and V2 receptor binding and their second messengers, inositol phosphate and adenylate cyclase, respectively, in liver and kidney to deter...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1992-10, Vol.20 (4), p.569-574
Hauptverfasser:	Trinder, Deborah, Phillips, Paddy A, Risvanis, John, Stephenson, Jayne M, Johnston, Colin I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - biosynthesis Animals Arginine Vasopressin Blood Pressure - drug effects Desoxycorticosterone - pharmacology Disease Models, Animal Hypertension - etiology Inositol Phosphates - biosynthesis Kidney - metabolism Liver - metabolism Male Osmolar Concentration Rats Rats, Inbred Strains Receptors, Vasopressin - drug effects Receptors, Vasopressin - physiology Second Messenger Systems Sodium Chloride - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Since arginine vasopressin may play a role in mlneralocorticoid hypertension, we examined the effects of deoxycorticosterone acetate (DOCA)-salt on vasopressin V1 and V2 receptor binding and their second messengers, inositol phosphate and adenylate cyclase, respectively, in liver and kidney to determine whether altered vasopressin receptor binding is pathogenetic in mineralocorticoid hypertension. The mean arterial blood pressure of mineralocorticoid (DOCA-salt)-treated rats (163±1 mm Hg) was increased compared with control salt-treated rats (salt) (122±1 mm Hg) and water-treated rats (120±1 mm Hg;p
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.HYP.20.4.569