The uptake of anionic and cationic amino acids by the isolated perfused sheep choroid plexus

The carrier-mediated uptake of anionic and cationic amino acids by the basolateral face (blood side) of the isolated perfused sheep choroid plexus was demonstrated using the paired-tracer dilution technique. The uptake of these two classes of amino acid was higher than at the blood-brain barrier wit...

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Veröffentlicht in:	Brain research 1992-05, Vol.581 (2), p.351-355
Hauptverfasser:	Preston, J.E., Segal, M.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid Animals Arginine Arginine - metabolism Aspartate Aspartic Acid - metabolism Biological and medical sciences Biological Transport - drug effects Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrospinal fluid Choroid plexus Choroid Plexus - metabolism Epithelium Female Fundamental and applied biological sciences. Psychology Glutamate Glutamates - metabolism Glutamates - pharmacology In Vitro Techniques Kinetics Lysine Lysine - metabolism Lysine - pharmacology Male Perfusion Sheep Vertebrates: nervous system and sense organs
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Zusammenfassung:	The carrier-mediated uptake of anionic and cationic amino acids by the basolateral face (blood side) of the isolated perfused sheep choroid plexus was demonstrated using the paired-tracer dilution technique. The uptake of these two classes of amino acid was higher than at the blood-brain barrier with no cross-competition between them. In addition the uptake was markedly stereospecific with a high degree of selectivity and no interaction with the ‘ l’-system amino acids.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(92)90731-N