More kapakahines from the marine sponge Cribrochalina olemda

Three new kapakahines E-G (1-3) have been isolated from the marine sponge Cribrochalina olemda. Limited quantities of these compounds required not only NMR analysis but also FAB-MS/MS analysis for the structure elucidation. Kapakahine E showed cytotoxicity against P388 murine leukemia cells. [struct...

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Veröffentlicht in:	Organic letters 2003-05, Vol.5 (9), p.1387-1390
Hauptverfasser:	Nakao, Yoichi, Kuo, Jacqueline, Yoshida, Wesley Y, Kelly, Michelle, Scheuer, Paul J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Drug Screening Assays, Antitumor Leukemia P388 Nuclear Magnetic Resonance, Biomolecular Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Porifera - chemistry Spectrometry, Mass, Fast Atom Bombardment Stereoisomerism Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Three new kapakahines E-G (1-3) have been isolated from the marine sponge Cribrochalina olemda. Limited quantities of these compounds required not only NMR analysis but also FAB-MS/MS analysis for the structure elucidation. Kapakahine E showed cytotoxicity against P388 murine leukemia cells. [structure: see text]
ISSN:	1523-7060
DOI:	10.1021/ol026830u