Elevated CSF Glutamate in Rett Syndrome

Abstract The concentration of free amino acids was measured in the cerebrospinal fluid of four patients with Rett syndrome. The reference material were patients with autistic disorder who had CSF aminoacid levels similar to those reported for healthy children. The concentration of glutamate - but of...

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Veröffentlicht in:	Neuropediatrics 1992-08, Vol.23 (4), p.212-213
Hauptverfasser:	Hamberger, A., Gillberg, Chr, Palm, Anita, Hagberg, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acids - cerebrospinal fluid Autistic Disorder - cerebrospinal fluid Autistic Disorder - diagnosis Biological and medical sciences Child Diagnosis, Differential Female Glial Fibrillary Acidic Protein - cerebrospinal fluid Glutamates - cerebrospinal fluid Glutamic Acid Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Medical sciences Nervous system (semeiology, syndromes) Neurology Original article Rett Syndrome - cerebrospinal fluid Rett Syndrome - diagnosis
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Zusammenfassung:	Abstract The concentration of free amino acids was measured in the cerebrospinal fluid of four patients with Rett syndrome. The reference material were patients with autistic disorder who had CSF aminoacid levels similar to those reported for healthy children. The concentration of glutamate - but of no other amino acid - was markedly elevated in the CSF of the RS patients. The results are discussed in the context of excitotoxicity in neurodegenerative disease.
ISSN:	0174-304X 1439-1899
DOI:	10.1055/s-2008-1071344